BRCA1 and breast cancer: Nonetheless, few studies document benefits of short-term use of HRT (estrogen alone, not estrogen plus progesterone) on menopausal symptoms (endocrine and sexual) and on the adverse aging-related health effects of surgical menopause (e.g., on bones, cardiovascular system) among BRCA1/2 mutation carriers, with debates on the risk of breast cancer occurrence following long-term use of HRT [19,20,21,22,23].