TNF and hyperinsulinemic hypoglycemia, familial, 4: BRCA1 deficiency is associated with the activation of inflammatory signaling (tumor necrosis factor α (TNF-α) activation of nuclear factor kappa B (NF-κB) and mRNA expression of NF-κB-dependent target gene superoxide dismutase 2 (SOD2)), as well as increased production of free radicals, resulting in DNA damage, which triggers malignant transformation [9].