Moreover, numerous studies in mice have highlighted the importance of natural IgM in resistance to fungal infections through a variety of mechanisms, including the recruitment of macrophages and phagocytosis of fungi, the assistance in the recognition of fungal antigens by dendritic cells and their migration to lymph nodes, and the primary role of antibodies in generating memory anti-fungal immunity [31,32]. This evidence concerns the gene CD40LG and fungal infectious disease.