The univariate logistic regression analysis showed that higher ESSDAI (p = 0.011), presence of Raynaud’s phenomenon (p = 0.009), anti-Ro52 autoantibodies (either isolated or combined with anti-Ro60, p = 0.031), hypergammaglobulinemia (p = 0.011), RF (p = 0.038) and C4 hypocomplementemia (p = 0.044) at baseline were associated with increased risk of ILD development during follow-up. Here, RO60 is linked to interstitial lung disease.