Independent factors associated with the laboratory definition of CRT-D response (Table 8) were increased BMI (HR: 1.545, 95% CI: 1.023–2.332; p = 0.039), the absence of AF (HR: 0.369, 95% CI: 0.149–0.918; p = 0.032), the use of angiotensin-receptor–neprilysin inhibitor (ARNI) (HR: 2.717, 95% CI: 1.110–6.649; p = 0.029) and low baseline creatinine (HR: 0.455, 95% CI: 0.248–0.834; p = 0.011). The gene discussed is MME; the disease is atrial fibrillation.