Three studies presented IL-6 data suitable for meta-analysis (n = 140) and showed significantly lower serum IL-6 levels after diet-induced weight loss compared to baseline levels before weight loss in PCOS women (SMD 0.37, 95% Cl, 0.12, 0.61; z = 2.95; p =0.003; I2 = 90%). This evidence concerns the gene IL6 and polycystic ovary syndrome.