Meta-analysis of five studies (n = 197) showed a significant decrease in serum LH levels after weight loss compared to baseline levels before the diet intervention in PCOS women (SMD 0.30, 95% Cl, 0.09, 0.51; z = 2.78; p = 0.005; I2 = 84%). The gene discussed is PLOD1; the disease is polycystic ovary syndrome.