A meta-analysis of five studies (n = 173) with relevant data showed a significant increase in SHBG levels after diet-induced weight loss compared to baseline levels in PCOS women (SMD −0.43, 95% Cl, −0.65, −0.21; z = 3.84; p = 0.0001; I2 = 89%). Here, SHBG is linked to polycystic ovary syndrome.