Notably, among the ophthalmological variables, IL-5, G-CSF, and CCL11/eotaxin-1 concentrations were newly identified as tear inflammatory mediators predictive of the coexistence of T2DM after controlling for other prevalent cardiovascular risk factors (i.e., hypertension, hypercholesterolemia, obesity, smoking, sex, and age). The gene discussed is CSF3; the disease is Obesity.