RETN and stroke disorder: Among the numerous predictive factors that are known to increase stroke burden such as smoking, a high sodium diet, high blood arterial pressure, high low-density lipoprotein cholesterol, kidney dysfunction, high fasting plasma glucose, and high body mass index (BMI) or high National Institute of Health Stroke Scale (NIHSS) score, large lesion volume or comorbidity biomarkers like adipokines and, in particular, resistin and leptin, have become noticeable factors in AIS due to their roles in inflammation, metabolism, and cardiovascular health [3,6].