The opposite changes in vWF and ADAMTS13 in sepsis reflect the impact of systemic inflammation and released inflammatory cytokines such as inteleukin-6, interferon-gamma, and tissue necrosis factor (TNF)-alpha that stimulate vWF release but suppress ADAMTS13 synthesis in endothelial cells [27] and/or hepatic stellate cells [28]. Here, TNF is linked to Sepsis.