KLK3 and Familial prostate cancer: There are newer, readily available prognostic classifiers, such as multiparametric prostate magnetic resonance imaging (mpMRI) with fusion-targeted biopsy, cribriform growth in Gleason score 7 prostate cancer, the “third type” of tumor grade in the biopsy (added as the third denominator to the Gleason score), neutrophil-to-lymphocyte ratio and PSA density.