MSH6 and familial pancreatic carcinoma: A study by Kastrinos et al. on 147 families with mutations in MLH1, MSH2, or MSH6 genes showed an 8.6-fold increase in the risk of pancreatic cancer as compared to the general population, and the estimated cumulative risk of developing pancreatic cancer was 1.3% up to the age of 50 years and 3.7% up to the age of 70 years [25].