This was supported by a Danish cohort study of 309,166 patients with diabetes, which similarly showed that GLP-1 RAs were associated with a 50% lower rate of diabetes-associated amputations compared to those not on GLP-1 RA treatment (HR 0.50, 95% CI [0.54–0.74], p < 0.005) [76]. The gene discussed is GLP1R; the disease is diabetes mellitus.