In the same line as APOE, recent genome-wide association studies ((GWAS) reported over 30 genetic loci (CLU, PICALM, CR1, BIN1, EPHA1, MS4A, ABCA7, CD33, and CD2AP) associated with late-onset AD risk, highlighting the polygenic nature of the disease [68,69,70,71]. Here, PICALM is linked to Alzheimer disease.