In obese subjects, the condition of insulin resistance is associated with altered functioning of the renin-angiotensin-aldosterone system (adipose tissue favors the production of factors capable of increasing the production of angiotensinogen and aldosterone) [24], which causes a high expression of ACE2 in adipose tissue cells constituting privileged access to the SARS-CoV-2 virus. This evidence concerns the gene REN and Insulin resistance.