To illustrate the connection between the gut and the brain, a Spearman correlation analysis was conducted between intestinal microbes and phenotypic indicators of depression, including body weight, 5-HT, BDNF, TNF-α, NF-κB, etc. As shown in Figure 8A, pro-inflammatory factors such as TNF-α and NF-κB were distributed separately in the fourth quadrant and were strongly correlated with the model group, while factors such as body weight and neurotransmitter (5-HT, BDNF) were concentrated in the third and fourth quadrants and were highly correlated with normal and jasmine tea intervention groups. Here, TNF is linked to major depressive disorder.