The results were consistent with significantly elevated levels of TNF-alpha identified in a cross-sectional study comprising 117 obese (BMI ≥ 30) and 83 non-obese, community-based volunteers [15], and a longitudinal study that showed a significant difference in hs-CRP values across all obesity categories [16]. The gene discussed is TNF; the disease is obesity due to melanocortin 4 receptor deficiency.