CHI3L1 and colonic neoplasm: Among the inflammatory marker panel we analysed chitinase-3-like 1 [1,56], IL-8 [57,58] and IL-32 [59,60] expression contributes to pro-inflammatory environment and are associated with an overall negative health outcome while the expression of IL-35 is considered an inflammatory dampener being associated with overall positive health outcomes for colon cancer patients [61,62].