Additionally, NRG has demonstrated strong inhibitory effects on the growth of C6 glioma cells in rat brains by reducing the levels of several important molecules, including protein kinase C, nuclear factor kappa B (NF-κB), cyclin D1, and cyclin-dependent kinase 4 (CDK4), as well as by mitigating oxidative stress [6]. This evidence concerns the gene CDK4 and central nervous system cancer.