Human endometrial cells from the eutopic endometrium of patients with endometriosis showed increased expressions of aldo-keto reductase (AKR) 1C1, AKR1C2, AKR1C3, and AKR1B10 after exposure to DEHP, so they may play a role in the development of endometriosis through the resistance to progesterone and prostaglandin synthesis [46]. This evidence concerns the gene AKR1C3 and endometriosis.