Moreover, the dosage of circulating levels of EGFL7 has an additional diagnostic and prognostic value in comparison to s-Flt1 and PlGF or s-Endoglin (sEng), since it is not only detectable in maternal blood before the clinical manifestation of PE, but it also allows us to efficiently discriminate between pregnancies affected by PE and those with isolated IUGR [13,37]. This evidence concerns the gene PGF and fetal growth restriction.