The pathologies in animals #17012 and #17020 (i.e., pleural effusions, increase in inflammatory markers, humoral rejection, see above) clearly manifested after decreasing the anti-CD40 IgG4 and anti-CD40L PAS-Fab doses, and there were no comparable events in the animals #16956 and #16935, which were deliberately terminated after 90 postoperative days. The gene discussed is CD40LG; the disease is Pleural effusion.