ZEB1/2 transcription factor dysregulation has previously been demonstrated to play pathological roles in the EMT processes involved in (1) the malignant dissemination (metastasis) of epithelial-derived tumor cells [118,119], (2) the acquisition of cancer or tumor stem cell properties [120,121], and (3) the development of treatment resistance [122,123]. Here, ZEB1 is linked to neoplasm.