NUCB2 and colitis: To decipher its mechanisms, three subgroups of the nesfatin-1 group were created 5 min after colitis induction, each of them receiving intracerebroventricularly growth hormone (GH) secretagogue receptor-1a (GHSR-1a) antagonist (antagonist of ghrelin receptors), atosiban (antagonist of oxytocin receptor), and trifluoroacetate salt SHU9119 (antagonist of melanocortin receptors) followed 5 min later by the administration of nesfatin-1 for 3 days.