Different mechanisms are involved in the development of arterial hypertension and its complications, including increased activity of the renin-angiotensin system through an increase in the hepatic synthesis of angiotensinogen, concomitant up-regulation of angiotensin II type 1A receptors) [32], endotheliopathy is characterised by an imbalance in the vasoregulatory system, reduced bioavailability of vasodilators, increased synthesis of vasoconstrictors such as endothelin 1, and increased vascular reactivity to vasopressors [33]. This evidence concerns the gene EDN1 and Hypertension.