Another recent umbrella review and meta-analysis study of 3,046,661 diabetic patients from 100 reviews and 27 cohort/case-control studies, treated with different anti-diabetic drugs, highlighted how treatment with SGLT2 Is, metformin, thiazolidinediones or GLP-1 RAs was associated with a lower risk of dementia [164]. Here, GCG is linked to dementia.