PSEN2 and early-onset autosomal dominant Alzheimer disease: Regarding the role of mutations that give rise to familial Alzheimer’s disease and, more particularly, those of PSEN2 in the development of cerebral amyloid angiopathy (CAA), there are several reports of patients in whom intracranial hemorrhages were described, mostly in the cohort with the p.Asn141Ile mutation [36].