P2RX7 and Hyperglycemia: A decreased Klotho level increased the purinergic receptor P2X7, causing cell apoptosis or necrosis, as well as suppressed the hyperglycemia-mediated glomerular endothelial injury and activation of the Wnt/β-catenin pathway in mice models of diabetic nephropathy, implicating Klotho’s possible role in pathophysiology of NS [78].