Indeed, the concept of “prediabetes” is based on a predictive model that utilized the high composite risk of developing diabetes mellitus and CVD, including acute myocardial infarction, heart failure and asymptomatic atherosclerosis, by potentiating the effects of metabolic abnormalities, such as hyperglycemia, lipid toxicity, insulin resistance and concomitant metabolic condition, including abdominal obesity [2]. Here, INS is linked to diabetes mellitus.