Its antimicrobial effects against pathogenic gut bacteria, as well as its cholesterol-lowering, anti-inflammatory, and antioxidant properties observed in other studies, might explain our results, which showed that the L. plantarum supplement could improve NASH histopathology, reduce the number of TLR4- and CD14-positive cells in the liver, and lower serum TNF-α and IL-6 levels. Here, TLR4 is linked to metabolic dysfunction-associated steatohepatitis.