Th1 cells, prevalent in the plaques, accelerate atherosclerosis progression by secreting pro-inflammatory cytokines [16], including interferon gamma (IFN-γ) and interleukin 2 (IL-2), (although IL-2 plays a role in the differentiation of Tregs, it can promote T-cell proliferation, activate NK cells, and increase their toxicity, exhibiting strong pro-inflammatory properties) [17,18,19]. Here, IFNG is linked to atherosclerosis.