In addition to correlations with amyloid- and tau-PET status, plasma p-tau217 has been shown to differentiate pathologically diagnosed AD from non-AD with significantly higher accuracy than p-tau181, with an area under the curve (AUC) of 0.88–0.90 compared to p-tau181’s AUC of 0.72–0.81 [26,59,60]. This evidence concerns the gene MAPT and Alzheimer disease.