AKT1 and neoplasm: The overexpression of 7-dehydrocholesterol reductase in cholesterol metabolism can accelerate tumor growth in the G0/G1 phase through the phosphoinositide 3 kinase/protein kinase B (AKT)/mTOR signaling pathway, can antagonize cell apoptosis, and can enhance cell invasion and migration capabilities and epithelial–mesenchymal transition [38].