For example, Teijieira et al. [17] showed that tumor-secreted CXCR1 and CXCR2 ligands, such as IL-8, induced the extrusion of NETs, which wrapped and coated tumor cells and physically shielded them from CD8+ T cell- and NK cell-mediated cytotoxicity in mice. This evidence concerns the gene CXCR1 and neoplasm.