In osteoporosis, cytokines, among osteoclasts and osteoblasts, including Tumor Necrosis Factor (TNF), the interleukin (IL) family, and growth factors (GFs), play crucial roles in bone remodeling, with the RANKL/RANK/OPG axis being essential within the cytokine networks and signaling pathways [11]. Here, TNFSF11 is linked to osteoporosis.