Potential molecular mechanisms contributing to functional, morphological, and structural impairments, known as diabetes-induced cardiomyopathy, affect altered cardiac metabolism, and are the result of the following: glucose and lipid toxicity, mitochondrial DNA damage, insulin resistance and impaired cardiac insulin metabolic signaling, cardiac myocytes endoplasmic reticulum stress, mitochondrial stress and dysfunction due to oxidative stress, inflammation, neurohumoral activation and adipose tissue dysfunction, impaired vascular integrity, and endothelial dysfunction [4,5]. This evidence concerns the gene INS and endothelial dysfunction.