Both mTOR complexes, mTORC1 and mTORC2, are activated in ADPKD [78,79], and inhibiting these pathways has been effective in reducing cyst growth and improving renal function by preventing epithelial cell proliferation, reducing fibrosis, and stimulating apoptosis of lining cells in a murine experimental model [80]. The gene discussed is MTOR; the disease is cyst.