The results of our study demonstrate that H2O2 oxidative eustress and JNK inhibition can differentially regulate Wnt/β-catenin signaling and APC expression in primary and metastatic CRC cells, suggesting a role in the molecular relationship between JNK and Wnt/β-catenin functions in response to the oxidation state of TME (Figure 4, Figure 5 and Figure 7). The gene discussed is APC; the disease is colorectal carcinoma.