Considering the role of H2O2 in carcinogenesis, it is important to know how this molecule could remodulate the Wnt signaling in CRC progression and to evaluate the molecular relationship between oxidative stress and JNK/Wnt/β-catenin in primary SW480 and metastatic SW620 CRC cell models derived from the same patient. Here, MAPK8 is linked to colorectal carcinoma.