In addition, mutations on growth differentiation factor 2 (GDF2) (also known as bone morphogenetic protein 9 (BMP9)) have been rarely (<1%) detected in HHT-like syndromes, which are distinguished by patients suffering from recurrent epistaxis, telangiectasia, and other symptoms associated with HHT, along with a family history of similar complaints [20,24,25,26]. This evidence concerns the gene GDF2 and hereditary hemorrhagic telangiectasia.