IL1B and Sepsis: In mice injected with phosphate-buffered saline (PBS), low-dose (systemic infection dose) or high-dose PSP (same concentration seen during sepsis) following cecal ligation and puncture (CLP), the level of inflammatory factors (TNF-α, IL-6, IL1-β), key parameters reflecting organ failure (lactate dehydrogenase, troponin, creatinine, lung wet/dry ratio), the disease severity score, and mortality were directly correlated with the doses of PSP injected [30].