Although studies are still needed to elucidate the pathways of sepsis and PMN activation, it can be hypothesized that during sepsis, PSP (a C-type lectin-like protein) might be a DAMP-like activating C-type lectin receptors (CLRs) (one of the four PRRs; see Figure 1) involved in the host response to pathogens by activating PMNs, thus reflecting the protein kinase cascade activation and progression to MODS. The gene discussed is REG1A; the disease is Sepsis.