It is thought that mutations in U2AF1 and SF3B1 create long isoforms of IRAK4 (IRAK4-long, or IRAK4-L), which are important in leukemogenesis; this creates a rationale for further research into the development of inhibitors of IRAK4, such as CA-4948 in AML [154,155,156]. Here, SF3B1 is linked to acute myeloid leukemia.