PARP1 and malignant colon neoplasm: PARP1 upregulation has been reported in several malignancies, including oral cancer [61], ovarian cancer [62], testicular tumors [63], neuroblastoma [64], malignant lymphoma [65], breast cancer [66,67], colon cancer [68], endometrial cancer [69], and BRCA-mutated ovarian cancer [70,71].