NFE2L2 and Parkinson disease: A key regulator of ferroptosis, nuclear factor erythroid 2-related factor 2 (NRF2), was found to be upregulated in rat striatum after physical exercise, and it has been reported that this protects against MPP+-induced neurodegeneration of dopaminergic neurons and ameliorates motor manifestations in a rotenone rat model of PD [158,159,160].