-The synbiotic supplementation was able to modify the gut microbiota in the synbiotic group with an increase in butyrate-producing bacteria and butyrate metabolism. These patients demonstrated a significant reduction in serum IL-6 levels, suppression of the increase in high-sensitivity C-reactive protein (hs-CRP) levels, and an improvement in SLE disease activity scores as measured by SLEDAI-2K. The gene discussed is IL6; the disease is systemic lupus erythematosus.