After this interaction, the autophagy-related gene MAP1LC3B’s expression is controlled adversely by SpoE. This research demonstrated that SopE may play two distinct roles in the regulation of autophagy: after the initial rise in MAP1LC3B transcription brought on by Salmonella infection, the subsequent decrease in MAP1LC3B transcription at 6 h after infection was reliant on Sop. Here, MAP1LC3B is linked to Salmonella Infections.