Studies in experimental models of hypertension, including RVH, showed that treatment with LA was able to generate a variety of beneficial effects, involving reduced expression of NADPH oxidase subunits, in addition to attenuating sympathetic hyperexcitation [16], improving baroreflex sensitivity [10,11] and increasing SOD and glutathione (GSH) levels [17]. This evidence concerns the gene FMO5 and hypertensive disorder.