Several studies have detected IL-1β and IL-8 in the serum and saliva (IL-1β 0.5–12 pg/mL; IL-8 < 62 pg/mL) of patients with oral squamous cell carcinoma (OSCC), highlighting their significance as biomarkers for oral cancer [18,19]. This evidence concerns the gene CXCL8 and oral cavity squamous cell carcinoma.