Transcriptomic profiling of these two myeloid clusters revealed an upregulation of chemoattractant SASP factors such as secreted phosphoprotein 1 (Spp1), MHC genes, lysosomal stress markers (Lgals3 and Lgals3bp), and senescence-related genes (Cdkn2a, Cdkn1a, and B cell Lymphoma (Blc2)). The gene discussed is SPP1; the disease is lymphoma.