The data obtained indicate that the upstream component of the Wnt signaling pathway could have a significant impact on the advancement of colon cancer, which is consistent with a recent investigation on colorectal cancer that found high levels of Wnt3a expression in both primary and metastatic locations, and its strong correlation with the presence of the metastasis-related protein matrix metalloproteinase (MMP)-9 [72]. Here, WNT3A is linked to colonic neoplasm.