WNT5A and malignant colon neoplasm: Meanwhile, the methylation of the Wnt5a promoter was closely linked to the microsatellite instability status of colorectal cancer (CRC) patients, and various histone modifications of Wnt5a participated in its suppression and could potentially encourage the spread of colon cancer, suggesting that epigenetic processes might improve the Wnt5a-mediated signaling in CRC [80,81].