Xu et al. demonstrated that the overexpression of the erythropoietin-producing hepatocyte (EphB6), a member of the tyrosine kinase family, along with APC gene mutations, increases proliferation, migration, and invasion in the colon epithelial cell line, IMCE, supporting the role of APC mutations in promoting tumorigenesis in CRC [50]. Here, EPHB6 is linked to colorectal carcinoma.