To further explore this supposed synergism between the two systems, we compared APLNR’s expression with the expression of nNOS in two different stages of AH and hypertension-induced kidney injury—at the onset of AH (6-month-old SHRs) and in advanced AH (12-month-old SHRs)—and compared it to age-matched WRs as controls. Here, NOS1 is linked to Hypertension.