CCR3 and chronic rhinosinusitis: When eotaxin links to its most specific receptor, CCR3, in organs and the brain, it recruits eosinophils that upon degranulation release eosinophil granule proteins, growth factors, and cytokines causing cellular damage; eotaxin plays a central role in mediating a number of eosinophilic disorders, including atopic dermatitis, eosinophilia in asthma, chronic rhinosinusitis, and eosinophilic esophagitis [58,59].