KDR and cancer: Table 3 also includes a positive score for gene-expression connectivity with epinephrine for vascular endothelial growth factor receptor (VEGFR) inhibitors; this is commented upon below. Quite remarkably, the CLUE output in Table 3 also includes a positive score for connectivity of epinephrine with rapidly accelerated fibrosarcoma (RAF) inhibitors. The proto-oncogene B-RAF is part of the pathway of RAF activation of many cancers [52].