Besides classical factors like HT, diabetes, obesity, and dyslipidemia, several specific abnormalities explain the high prevalence of CVD in CKD: the activation of the renin–angiotensin–aldosterone system, extracellular volume expansion, increased sympathetic activity, chronic inflammation, oxidative stress, mineral bone disease, accumulation of uremic toxins, etc. [3]. This evidence concerns the gene REN and chronic kidney disease.