Statistical analysis in some studies proved that increased plasma renalase in CKD can be used as a marker for the prediction of the occurrence of cardiovascular disease [28], hypertension [28], left ventricular hypertrophy [45,47], coronary artery disease [48], major adverse cardiovascular events [29], and cardiac and all-cause death [29,36,42,46]. The gene discussed is RNLS; the disease is hypertensive disorder.